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| α-Synuclein (67-78) (human) trifluoroacetate salt | ||
| Catalog Number | 335P93 | |
| Three Letter Code | H-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-OH trifluoroacetate salt | |
| One Letter Code | GGAVVTGVTAVA | |
| Molecular Formula | C₄₃H₇₆N₁₂O₁₅ | |
| Relative Molecular Mass | 1001.14 | |
| Source | Synthetic | |
| Storage Conditions | -20 ± 5 °C | |
| Areas of Interest | Alzheimer's Disease Parkinson’s Disease | |
| Details | ||
| The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol. | ||
| 报价或需更多信息请发邮件至：alex@hanhonggroup.com， 我们一定在第一时间回复您！ | ||
Parameters
| Properties | |
| Properties | 白色结晶粉末。 |
|---|---|
| Toxicity information | 仅用于科学研究。 |
| Specification And Standard | |
| SPEC1 | 根据客户的要求提供从60%至98%不同HPLC纯度的产品。 |
| Production And Usage | |
| Production process | SPPS固相法化学合成。 |
| Application | Alzheimer's Disease |Parkinson’s Disease |
| Packing And Storage | |
| Packing | 冷存管，根据客户要求提供每管不同数量的包装。 |
| Storage | -20 ± 5 °C低温避光保存。 |
| Safety | |
| Spectrum And References | |
| 1H NMR | 根据客户的要求提供，但需额外检测费用。 |
| 13C NMR | 根据客户的要求提供，但需额外检测费用。 |
| MS | 发货时这个产品的MS，HPLC图谱及质检报告将一并提供。 |
| Contact Salesman | |
| Buy reagents | 邮箱alex@hanhonggroup.com, 手机：19961912513（微信同号） |
| Buy Bulk | 请联系alex@hanhonggroup.com |
