Hot Sales
Perfluoro-1,3-dim...
|
DOPA-Phe-Phe-OH
|
Ethyl...
|
(2R,3R,4S,5R)-2-(...
|
1-(Benzo[d][1,3]d...
|
1-(4-Isobutylphen...
|
(2-ethylbutyl...
|
(S)-2-ethylbutyl...
|
Recent Browse
α-Synuclein (34-45) (human) trifluoroacetate salt | ||
Catalog Number | 335P90 | |
Three Letter Code | H-Lys-Glu-Gly-Val-Leu-Tyr-Val-Gly-Ser-Lys-Thr-Lys-OH trifluoroacetate salt | |
One Letter Code | KEGVLYVGSKTK | |
Molecular Formula | C₅₉H₁₀₁N₁₅O₁₈ | |
Relative Molecular Mass | 1308.52 | |
Source | Synthetic | |
Storage Conditions | -20 ± 5 °C | |
Areas of Interest | Alzheimer's Disease Parkinson’s Disease | |
Details | ||
The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol. | ||
报价或需更多信息请发邮件至:alex@hanhonggroup.com, 我们一定在第一时间回复您! |
Parameters
Properties | |
Properties | 白色结晶粉末。 |
---|---|
Toxicity information | 仅用于科学研究。 |
Specification And Standard | |
SPEC1 | 根据客户的要求提供从60%至98%不同HPLC纯度的产品。 |
Production And Usage | |
Production process | SPPS固相法化学合成。 |
Application | Alzheimer's Disease |Parkinson’s Disease |
Packing And Storage | |
Packing | 冷存管,根据客户要求提供每管不同数量的包装。 |
Storage | -20 ± 5 °C低温避光保存。 |
Safety | |
Spectrum And References | |
1H NMR | 根据客户的要求提供,但需额外检测费用。 |
13C NMR | 根据客户的要求提供,但需额外检测费用。 |
MS | 发货时这个产品的MS,HPLC图谱及质检报告将一并提供。 |
Contact Salesman | |
Buy reagents | 请联系alex@hanhonggroup.com |
Buy Bulk | 请联系alex@hanhonggroup.com |