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α-Synuclein (34-45) (human) trifluoroacetate salt

HPLC >95%

  • Commodity number:335P90
  • Goods number:335P90-5mg
  • Income integral:38
  • Abbreviation: KEGVLYVGSKTK
  • MF: C₅₉H₁₀₁N₁₅O₁₈
  • Synonyms: H-Lys-Glu-Gly-Val-Leu-Tyr-Val-Gly-Ser-Lys-Thr-Lys-OH trifluoroacetate salt
  • MW: 1308.52
  • Original price: ¥0.00
  • Present price: ¥384.00-¥1116.00
Freight number Package Original price Present price Order quantity Stock describe
335P90-5mg 5mg ¥0.00 ¥384.00
0 10个工作日内发货
335P90-25mg 25mg ¥0.00 ¥600.00
0 10个工作日内发货
335P90-100mg 100mg ¥0.00 ¥1116.00
0 10个工作日内发货
α-Synuclein (34-45) (human) trifluoroacetate salt
Catalog Number 335P90
Three Letter Code H-Lys-Glu-Gly-Val-Leu-Tyr-Val-Gly-Ser-Lys-Thr-Lys-OH trifluoroacetate salt
One Letter Code KEGVLYVGSKTK
Molecular Formula    C₅₉HN₅O
Relative Molecular Mass  1308.52
Source   Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest  Alzheimer's Disease
Parkinson’s Disease
Details
The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol. 
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Parameters

Properties
Properties白色结晶粉末。
Toxicity information仅用于科学研究。
Specification And Standard
SPEC1根据客户的要求提供从60%至98%不同HPLC纯度的产品。
Production And Usage
Production processSPPS固相法化学合成。
ApplicationAlzheimer's Disease |Parkinson’s Disease
Packing And Storage
Packing冷存管,根据客户要求提供每管不同数量的包装。
Storage-20 ± 5 °C低温避光保存。
Safety
Spectrum And References
1H NMR根据客户的要求提供,但需额外检测费用。
13C NMR根据客户的要求提供,但需额外检测费用。
MS发货时这个产品的MS,HPLC图谱及质检报告将一并提供。
Contact Salesman
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