current location： Index » Ⅰ.Amino Acids,Protected Amino Acids &Peptide Synthesis » 2.Peptides » 2.2. Peptides » 2.2.2.Catalogue Peptides » Miscellaneous » 
Hot Sales
Perfluoro-1,3-dim...
|
DOPA-Phe-Phe-OH
|
Ethyl...
|
(2R,3R,4S,5R)-2-(...
|
1-(Benzo[d][1,3]d...
|
1-(4-Isobutylphen...
|
(2-ethylbutyl...
|
(S)-2-ethylbutyl...
|
Recent Browse
 |
| Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH₂ | |
| Catalog Number | 332P2097 |
| Three Letter Code | Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH₂ |
| One Letter Code | Ac-FEWTPGWYQ-Aze-YALPL-NH₂ |
| Synonyms | AF12198 |
| Molecular Formula | C₉₆H₁₂₃N₁₉O₂₂ |
| Relative Molecular Mass | 1895.15 |
| CAS Registry Number | 185413-30-3 |
| Source | Synthetic |
| Storage Conditions | -20 ± 5 °C |
| Areas of Interest | Cytokines/Chemokines & their Receptors |
| Details | AF12198 exhibited both in vitro and in vivo IL-1 antagonist activity. It selectively bound the human type I IL-1 receptor but not the human type II receptor or the murine type I receptor. In vitro, AF12198 inhibited IL-1-induced IL-8 production by human dermal fibroblasts with an IC₅₀ of 25 nM and IL-1-induced intercellular adhesion molecule-1 expression by endothelial cells with an IC₅₀ of 9 nM. In vivo it blocked ex-vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6. This is the first small molecule which shows IL-1 receptor antagonist activity in vivo. |
| 报价或需更多信息请发邮件至：alex@hanhonggroup.com， 我们一定在第一时间回复您！ | |
Parameters
| Properties | |
| Properties | 白色结晶粉末。 |
|---|---|
| Toxicity information | 仅用于科学研究。 |
| Specification And Standard | |
| SPEC1 | HPLC纯度: >95% |
| Production And Usage | |
| Production process | SPPS固相法化学合成。 |
| Application | Cytokines/Chemokines & their Receptors |
| Packing And Storage | |
| Packing | 冷存管，根据客户要求提供每管不同数量的包装。 |
| Storage | -20 ± 5 °C低温避光保存。 |
| Safety | |
| Spectrum And References | |
| 1H NMR | 根据客户的要求提供，但需额外检测费用。 |
| 13C NMR | 根据客户的要求提供，但需额外检测费用。 |
| MS | 发货时这个产品的MS，HPLC图谱及质检报告将一并提供。 |
| Contact Salesman | |
| Buy reagents | 邮箱alex@hanhonggroup.com, 手机：19961912513（微信同号） |
| Buy Bulk | 请联系alex@hanhonggroup.com |
