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6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt | |
Catalog Number | 301P05 |
Three Letter Code | Fluorescein-6-carbonyl-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH trifluoroacetate salt(Disulfide bonds between Cys³ and Cys³⁵/Cys¹² and Cys²⁸/Cys¹⁷ and Cys³²) |
One Letter Code | Fluorescein-6-carbonyl-AEEAc-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC |
Synonyms | 6-FAM-AEEAc-ShK, ShK-F6CA |
Molecular Formula | C₁₉₆H₂₉₅N₅₅O₅₇S₇ |
Relative Molecular Mass | 4558.3 |
CAS Registry Number | 1927927-42-1 |
Source | Synthetic |
Storage Conditions | -20 ± 5 °C |
Areas of Interest | Ion Channel Modulating Agents |
Details | This ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the ƒ-amino group of Arg¹, selectively blocked the voltage gated T-lymphocyte K⁺ Kv1.3 channels implicated in the pathogenesis of experimental autoimmune encephalomyelitis. It potently blocked Kv1.3 channels at picomolar concentrations and exhibited >80 fold specificity for Kv1.3 over Kv1.1 and other Kv channels. In flow cytometry experiments, chronically activated rat and human T-lympocytes with >600 Kv1.3 channels/cell were readily distinguished from resting and acutely activated T-lymphocytes with lower Kv1.3 channel numbers. 6-FAM-AEEAc-Stichodactyla helianthus neurotoxin (ShK) may therefore be a useful tool to detect the presence of T-lymphocytes with high expression of Kv1.3 channels in normal and diseased tissues. |
报价或需更多信息请发邮件至:alex@hanhonggroup.com, 我们一定在第一时间回复您! |
Parameters
Properties | |
Properties | 白色结晶粉末。 |
---|---|
Toxicity information | 仅用于科学研究。 |
Specification And Standard | |
SPEC1 | HPLC纯度: >95% |
Production And Usage | |
Production process | SPPS固相法化学合成。 |
Application | Ion Channel Modulating Agents |
Packing And Storage | |
Packing | 冷存管,根据客户要求提供每管不同数量的包装。 |
Storage | -20 ± 5 °C低温避光保存。 |
Safety | |
Spectrum And References | |
1H NMR | 根据客户的要求提供,但需额外检测费用。 |
13C NMR | 根据客户的要求提供,但需额外检测费用。 |
MS | 发货时这个产品的MS,HPLC图谱及质检报告将一并提供。 |
Contact Salesman | |
Buy reagents | 邮箱alex@hanhonggroup.com, 手机:19961912513(微信同号) |
Buy Bulk | 请联系alex@hanhonggroup.com |