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Hepcidin-25 (human) trifluoroacetate salt | |
Catalog Number | 165P01 |
Three Letter Code | H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH trifluoroacetate salt(Disulfide bonds between Cys⁷ and Cys²³/Cys¹⁰ and Cys¹³/Cys¹¹ and Cys¹⁹/Cys¹⁴ and Cys²²) |
One Letter Code | DTHFPICIFCCGCCHRSKCGMCCKT |
Synonyms | LEAP-1 (human), Hepc25 (human), Liver-Expressed Antimicrobial Peptide (human), PLTR (human), Putative Liver Tumor Regressor (human) |
Molecular Formula | C₁₁₃H₁₇₀N₃₄O₃₁S₉ |
Relative Molecular Mass | 2789.4 |
CAS Registry Number | 1356390-47-0 |
Source | Synthetic |
Storage Conditions | -20 ± 5 °C |
Areas of Interest | Antimicrobial & Antiviral Peptides| Hematology |
Details | Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Further investigations revealed that hepicidin is the principal iron-regulatory hormone in humans. Hepcidin acts by binding to the iron exporter ferroportin, inducing its internalization and degradation, thereby blocking cellular iron efflux. Nemeth et al. demonstrated that the N-terminal part of the peptide hormone is essential for its activity. Former CAS-number 342790-21-0. |
报价或需更多信息请发邮件至:alex@hanhonggroup.com, 我们一定在第一时间回复您! |
Parameters
Properties | |
Properties | 白色结晶粉末。 |
---|---|
Toxicity information | 仅用于科学研究。 |
Specification And Standard | |
SPEC1 | HPLC纯度: >95% |
Production And Usage | |
Production process | SPPS固相法化学合成。 |
Application | Antimicrobial & Antiviral Peptides| Hematology |
Packing And Storage | |
Packing | 冷存管,根据客户要求提供每管不同数量的包装。 |
Storage | -20 ± 5 °C低温避光保存。 |
Safety | |
Spectrum And References | |
1H NMR | 根据客户的要求提供,但需额外检测费用。 |
13C NMR | 根据客户的要求提供,但需额外检测费用。 |
MS | 发货时这个产品的MS,HPLC图谱及质检报告将一并提供。 |
Contact Salesman | |
Buy reagents | 邮箱alex@hanhonggroup.com, 手机:19961912513(微信同号) |
Buy Bulk | 请联系alex@hanhonggroup.com |